Rasputin and aspirin

 
One of the most curious (and claims) from the beginning of the 20th century was the monk Gregorio Efimovich Rasputín, Almighty at the Court of Tsar Nicolás II. That power factors weighed, and much, the miraculous improvement of the son of the Tsar, Tsarevich, who suffered from hemophilia, when Rasputin persuaded the Tsar to abandon all medical treatment and entrusted it to his exclusive care (which consisted of spells and prayers). In 1916, fed up with him, the erratic course that printed Russian politics and its dictator in the middle of World War II, a group of nobles assassinated him through an effective combination of bullets and arsenic.
The magical healing of the Tsarevich, however, can be explained. Doctors were trying to his great patient with a drug brand. That drug, as it is now known, indirectly slow the clotting of the blood, and it is therefore contraindicated for haemophiliacs: there is nothing miraculous that the Tsarevich would improve as soon as I stopped taking it.
Nevertheless (and Rasputin), the drug in question more followed an ascending career and became more popular that Solomon, Kings and politicians to the point that today in day is the most widely used drug (and probably the cheapest) in the world. Everyone knows it, and it makes no sense continue hiding his name: neither more nor less than "aspirin", which was released by a German laboratory 10 of February 1899. In the postmodern ' GO, the world consumes the incredible figure of 100 billion tablets a year.
However, aspirin is a very old drug From the 1st century, already used the therapeutic virtues of the bark, leaves and SAP willow (which contains it) to calm fevers and headaches, but only in the century XIX is managed to extract and synthesize the active principle of the tradiciona­les concoctions: first the salicin, then the salicylic acid, cyclic and relatively simple molecules that were, however, serious problems of intolerance. In 1853, the young chemist Gerhardt managed the acetylation of salicylic acid and obtained the acid acetisalicilico: aspirin was acquiring its current and de­finitiva form. The discovery of Gerhardt, however, unnoticed from the pharmaceutical point of view until Félix Hoffmann (1867-1946) perfected a method of acetylation on an industrial scale, when the nineteenth century gave their latest described.
Probably the most remarkable in the history of aspirin is that, despite their massive employment, until very recently it ignored (and is still partly ignored) what are their mechanisms of action. In 1971 John Vane proposed a satisfactory explanation to show that aspirin inhibits the synthesis of prostaglandins, substances that accompany and motorized inflammations. By the way, as the prostaglandimis lower the threshold of pain receptors, this decreases. Because those jobs, Vane in 1982 received the Nobel Prize in medicine. But with Nobel Prize and all, the problem of the action of aspirin against pain (except in the case of pain that acom­paña to inflammations) remains open.
Now: apart from these actions (against inflammations and pain), friendly and lively acid ace­tilsalicilico has many other skills. Not all of them. recommended by the way: in the case of Kings, of very rare incidence syndrome, that only attacks children under one year and teens, manifested by severe disorders neurological and hepatic, aspirin can seriously make the situation worse, and even be fatal (some countries forbade aspirin in certain medicines). It also acts to retard the process of blood clotting, which contraindicated for haemophiliacs, as admirably illustrated by the episode of Rasputin. But in this case balances the goals: to retard blood clotting, help decrease the risk of blockages in arteries veins and, therefore, of strokes and heart attacks. The spectrum does not end there: aspirin acts on your huge amount of conditions, from colds to inflammatory rheumatisms, osteoarthritis, migraine headaches, sciatica, lumbago, and modern medical research is throwing the eye to your application ' in cases of cataracts and diabetes. It is something, by the way. "Poplar grows, Willow cries", say, highly derogatory way. It is very unfair because Willow contains the germ of acetylsalicylic acid as shown with the same attitude. At the end and ' out all over the world know that, many times, the so-called relieves pain.

HISTORY OF THE SICK CHILD 

The zarevitchdisease, was inherited from her mother, the Tsaritsa Alejandra Feodorovna, whose Catholic name was Alice von Hesse-Darmastad, daughter of the Grand Duke Luis IV and granddaughter of Queen Victoria. In addition to the madness of the family Von Hesse, which included 21 people with mental disorders, the beautiful Alice had led to the Romanovs hemophilia, hereditary disease transmitting mothers to sons. Presumably, in the origin of haemophilia, which killed a brother and an uncle of Alice, was the proud Queen of England.
The parents of the zarevitch have already renounced impotent science of physicians who roam the dark bedroom manners. The small Aliosha heartbreakingly complains.
In desperation, the Empress entrusted the cure of his son to the most unusual charlatans. Among them, the 'doctor' Philippe Vachot, a Parisian adventurer, former Assistant butcher, who for a time, and only thanks to his wisdom, was able to keep the trust of the tsars. Once unmasked, Vachot was returned without honours to his native France. It would then be the turn of Mitya Kolyaba, a disciple of the healer Darya Osipova, epileptic, that did pass his hysteria by States of true lighting. Their howls which most brushed the hysterics, did more than scare the ailing zarevitch.
The reasons for this candor in a cultured and energetic woman as the czarina Alejandra Feodorovna, can only be found in their on mysticism and his ardent faith, which bordered on superstition.
Discarded Science (which at that time had no answer for hemophilia), only him is God, or more exactly its so-called envoys, seeking to heal the boy through his Mystic ecstasy, that was the monk Rasputin.
Article translated for educational purposes from: Planeta Sedna