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What is the meaning of Pathogenesis? Concept, Definition of Pathogenesis

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Definition of pathogenesis


  • 1 Meaning of pathogenesis
  • 2. Definition of pathogenesis
  • 3 Concept of pathogenesis

1 Meaning of pathogenesis

The pathogenesis or nosogenia is the sequence of tissue and cellular events that take place from the moment of the initial contact with an Etiologic Agent until the final expression of the disease.
He studied the origin and development of diseases.
The study of the pathogenesis of diseases and syndromes clarifies the way in which a cause (etiology of the process) takes finally to produce a series of signs and symptoms. It is a term very similar to the physiopathology, while the latter refers to the functioning of the body (Physiology) in conditions of disease.
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2. Definition of pathogenesis

Pathogenesis is a branch of pathology that is dedicated to analyzing the origin of a morbid State. Its purpose is to study the events that are triggered from the action of an etiological factor and which reach up to the manifestation of the disease.
Also known as nosogenia, the pathogenesis investigates the emergence and development of conditions. Thanks to the pathogenesis, it is possible to know the etiology of discomfort (i.e., origin) and understand occur symptoms that the patient evidence. The pathogenesis is complemented with the pathophysiology, specifically oriented to the mode of function of the organism to develop health disorder.
What makes the pathogenesis, in short, is to study the process that leads to certain morbid factors to exert influence on a person's body, causing what is known as a disease. Addressing the pathogenesis, it is possible to focus on the functional section (pathophysiology) or morphological (pathology in its most general sense) issues.
It is important to highlight that each disease has its own pathogenesis. Psoriasis, tuberculosis, diverticulosis, and syphilis, to cite just a few examples, are disorders that are triggered for different reasons, which can be studied according to its pathogenesis.
Diseases affecting animals and are investigated and treated by veterinarians also have their pathogenesis. In the case of veterinary medicine, the notion has the same scope as in medicine, linked to the origin and the development of the disorder.


3 Concept of pathogenesis

Pathogenesis refers to the processes or mechanisms of generation of damage or disease, in this case, caused by a viral infection. The pathogenesis can be studied at different levels as it deemed as a guest to the cell, the individual or the community. The factors involved in its development can be classified into three groups that interact with each other:
Virus-dependent factors: are those inherent in the viral structure. In fact, known that only certain types of viruses can infect cells of the respiratory system and therefore cause disease as bronchopneumonia and other CNS and cause encephalitis. Even within them, some strains are most virulent (e.g. adenovirus 3 and 7 in respiratory diseases). Also, the amount of viral inoculum received an individual could determine if it induces a mild or severe infection.
The environment-dependent factors: conditions of the environment such as temperature, humidity, salinity, pH, ventilation, etc., may influence the viability of the virus before arriving at the host cell and affect its ability to infect. The presence of the lipoprotein mantle gives greater lability to the viral particle, therefore naked viruses better resist adverse environmental conditions.
Host-dependent factors: there are innate factors such as race, sex, immune status, nutritional status and others, that define the resistance or susceptibility to viruses; through specific cell receptors and ability to mount an immune response.
Other aspects related to the pathogenesis, represent a sum of factors of different type such as: work, travel, pregnancy, sexual behaviour, risk, etc., but are difficult to classify.

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